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KMID : 0363620080290010039
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 1 p.39 ~ p.46
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Acupuncture on ST36 Increases c-Fos Expression in vlPAG of Visceral Pain-induced Mice
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Choo Jin-Suk
Song Yun-Kyung
Lim Hyung-Ho
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Abstract
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Background: Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including pain relief. The descending pain control system of periaqueductal gray (PAG) is a powerful pain control system in mammalians. Expression of c-Fos is used as a marker for stimuli-induced metabolic changes of neurons.
Objective: In the present study, the effects of acupuncture on analgesic effect in visceral pain were investigated
through the writhing reflex and c-Fos expression in ventrolateral PAG (vlPAG) area using immunohistochemistry in mice.
Method: For the writhing test, mice were divided into five groups. Immediately after finishing the behavioral test,
the animals were weighed and overdosed with Zoletil. After a complete lack of response was observed, the brains of the mice were dissected into serial coronal sections, and c-Fos immunohistochemistry was performed. Statistical analysis of all data was performed using one-way ANOVA.
Result: The present results showed that acupuncture affected the writhing reflex and that Choksamni (zusnali)
acupoint and aspirin significantlysuppressed acetic acid treatment-induced increased writhing reflex, and the expression
of c-Fos in vlPAG was significantly increased in the acupunctured group.
Conclusion: The present study suggests that acupuncture has an antinociceptive effect on acetic acid-induced
visceral pain by increase of c-Fos expression in mice. Aspirin also showed analgesic effect, however the mechanism
is different from the acupuncture.
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KEYWORD
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Acupuncture, visceral pain, antinociceptive, c-Fos, vlPAG
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